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Brisbane, California-based Caption Health, maker of artificial intelligence-assisted ultrasound guidance software, has tied up a $53 million Series B funding round. Prior backer DCVC headed the raise. Atlantic Bridge and Edwards Lifesciences joined the round as new investors, while Khosla Ventures added onto its previous stake. The company's Caption AI software platform consists of two components, Caption Guidance and Caption Interpretation. The first uses AI to guide medical professionals though cardiac imaging that would normally be conducted by an ultrasound expert.

"I would love to see a future where looking inside the body becomes as routine as a blood pressure cuff measurement," says Charles Cadieu '04, MEng '05. As president of the medical technology startup Caption Health, he sees that future in reach--with the help of artificial intelligence. Cadieu still remembers the "lightbulb moment" during his postdoctoral research at MIT when he realized that the field of AI would never be the same. He was working in the lab of James DiCarlo (now the Peter de Florez Professor of Neuroscience) on neural networks--AI systems made up of deep-learning algorithms that emulate the dense networks of neurons in the brain. Until then, neural networks had been unable to perform even simple visual tasks that the brain handles with ease.

Caption Health, a leading medical AI company, announced that its flagship product, Caption AI, the first AI-guided medical imaging acquisition system, is now available for pre-order by healthcare providers. Caption AI is a transformational new technology that enables healthcare practitioners--even those without prior ultrasound experience--with the ability to perform ultrasound exams quickly and accurately, by providing expert guidance, automated quality assessment, and intelligent interpretation capabilities. Caption AI comes equipped with Caption Guidance software, which uses artificial intelligence to provide real-time guidance and feedback on image quality to enable capture of diagnostic quality images. This announcement follows the recent groundbreaking marketing authorization of Caption Guidance software by the U.S. Food and Drug Administration (FDA). The safety and effectiveness of Caption Guidance was clinically validated in a multi-center prospective pivotal trial at Northwestern Medicine and Minneapolis Heart Institute at Allina Health with registered nurses with no prior ultrasound experience.

The FDA has cleared what it describes as the first software that uses AI to guide family doctors, registered nurses and other clinicians in taking cardiac ultrasounds. Developed by Brisbane, California-based Caption Health, the software communicates instructions via prompts on a screen-based interface. The prompts allow non-experts to capture images and videos of diagnostic quality. "This is especially important because it demonstrates the potential for artificial intelligence and machine learning technologies to increase access to safe and effective cardiac diagnostics that can be life-saving for patients," Robert Ochs, a deputy director in the FDA's Center for Devices and Radiological Health, said in a statement. The software is called Caption Guidance and was cleared for use with a diagnostic ultrasound system developed by Teratech Corp., though the software has the potential to be used with other systems, according to the FDA. In granting clearance to the software, the agency said it looked at two independent studies.

Caption Health, a leading medical AI company, announced that the US Food and Drug Administration (FDA) authorized marketing of Caption Guidance, software that assists medical professionals in the acquisition of cardiac ultrasound images. Caption Guidance uses artificial intelligence to provide real-time guidance and diagnostic quality assessment of images, empowering healthcare providers--even those without prior ultrasound experience--with the ability to capture diagnostic quality images. Empowering more clinicians with ultrasound image acquisition capability will bring the benefits of ultrasound to more patients, help standardize the quality of care, and help institutions realize valuable cost and time savings. Caption Guidance was authorized via the De Novo pathway, a regulatory pathway reserved for novel technologies. The granting of this De Novo is groundbreaking, as Caption Guidance is the first medical software authorized by the FDA that provides real-time AI guidance for medical imaging acquisition.

Let's assume you are not an expert highly trained in medical imaging. And let's assume you were invited one day to try out a new technology for heart ultrasounds -- diagnostic tools that are notoriously difficult to use because of the chest wall and because some shots must be made while the heart is in motion. When I was given the shot on a recent day, I was able to take the ultrasound in a matter of minutes with the help of software, developed by a San Francisco-based startup called Caption Health. The software told me how to hold the ultrasound probe against the ribs of a model who had been hired for the purpose of my visit and knew on its own when to snap the image. It was a little like having Richard Avedon's knowledge of photography uploaded into the guts of my iPhone camera. You can see the image I took of the parasternal long axis view of the heart pumping at the top of this page.